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SEX-DEPENDENT EFFECTS OF CANNABIS-INDUCED ANALGESIA

Overview of attention for article published in Drug & Alcohol Dependence, August 2016
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802

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 3,128)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
101 news outlets
blogs
3 blogs
policy
1 policy source
twitter
18 tweeters
facebook
5 Facebook pages
googleplus
2 Google+ users
reddit
1 Redditor

Readers on

mendeley
29 Mendeley
Title
SEX-DEPENDENT EFFECTS OF CANNABIS-INDUCED ANALGESIA
Published in
Drug & Alcohol Dependence, August 2016
DOI 10.1016/j.drugalcdep.2016.08.001
Pubmed ID
Authors

Ziva D. Cooper, Margaret Haney, Cooper, Ziva D, Haney, Margaret

Abstract

Preclinical studies demonstrate that cannabinoid-mediated antinociceptive effects vary according to sex; it is unknown if these findings extend to humans. This retrospective analysis compared the analgesic, subjective and physiological effects of active cannabis (3.56-5.60% THC) and inactive cannabis (0.00% THC) in male (N=21) and female (N=21) cannabis smokers under double-blind, placebo-controlled conditions. Pain response was measured using the Cold-Pressor Test (CPT). Participants immersed their hand in cold water (4°C); times to report pain (pain sensitivity) and withdraw the hand (pain tolerance) were recorded. Subjective drug ratings were also measured. Among men, active cannabis significantly decreased pain sensitivity relative to inactive cannabis (p<0.01). In women, active cannabis failed to decrease pain sensitivity relative to inactive. Active cannabis increased pain tolerance in both men women immediately after smoking (p<0.001); a trend was observed for differences between men and women (p<0.10). Active cannabis also increased subjective ratings of cannabis associated with abuse liability ('Take again,' 'Liking,' 'Good drug effect'), drug strength, and 'High' relative to inactive in both men and women (p<0.01). These results indicate that in cannabis smokers, men exhibit greater cannabis-induced analgesia relative to women. These sex-dependent differences are independent of cannabis-elicited subjective effects associated with abuse-liability, which were consistent between men and women. As such, sex-dependent differences in cannabis's analgesic effects are an important consideration that warrants further investigation when considering the potential therapeutic effects of cannabinoids for pain relief.

Twitter Demographics

The data shown below were collected from the profiles of 18 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
United Kingdom 1 3%
Canada 1 3%
Unknown 26 90%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 24%
Researcher 4 14%
Student > Master 3 10%
Student > Ph. D. Student 3 10%
Professor 2 7%
Other 10 34%
Readers by discipline Count As %
Medicine and Dentistry 8 28%
Agricultural and Biological Sciences 6 21%
Psychology 6 21%
Unspecified 4 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 3 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 802. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2017.
All research outputs
#3,292
of 8,670,311 outputs
Outputs from Drug & Alcohol Dependence
#1
of 3,128 outputs
Outputs of similar age
#269
of 260,781 outputs
Outputs of similar age from Drug & Alcohol Dependence
#1
of 98 outputs
Altmetric has tracked 8,670,311 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,128 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,781 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.