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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation
|
|---|---|
| Published in |
Neuron, May 2016
|
| DOI | 10.1016/j.neuron.2016.04.043 |
| Pubmed ID | |
| Authors |
Christina M. Gremel, Jessica H. Chancey, Brady K. Atwood, Guoxiang Luo, Rachael Neve, Charu Ramakrishnan, Karl Deisseroth, David M. Lovinger, Rui M. Costa |
| Abstract |
Everyday function demands efficient and flexible decision-making that allows for habitual and goal-directed action control. An inability to shift has been implicated in disorders with impaired decision-making, including obsessive-compulsive disorder and addiction. Despite this, our understanding of the specific molecular mechanisms and circuitry involved in shifting action control remains limited. Here we identify an endogenous molecular mechanism in a specific cortical-striatal pathway that mediates the transition between goal-directed and habitual action strategies. Deletion of cannabinoid type 1 (CB1) receptors from cortical projections originating in the orbital frontal cortex (OFC) prevents mice from shifting from goal-directed to habitual instrumental lever pressing. Activity of OFC neurons projecting to dorsal striatum (OFC-DS) and, specifically, activity of OFC-DS terminals is necessary for goal-directed action control. Lastly, CB1 deletion from OFC-DS neurons prevents the shift from goal-directed to habitual action control. These data suggest that the emergence of habits depends on endocannabinoid-mediated attenuation of a competing circuit controlling goal-directed behaviors. |
X Demographics
The data shown below were collected from the profiles of 50 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 22% |
| Canada | 5 | 10% |
| United Kingdom | 5 | 10% |
| Italy | 2 | 4% |
| Spain | 2 | 4% |
| Japan | 2 | 4% |
| Ireland | 1 | 2% |
| Portugal | 1 | 2% |
| Germany | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 18 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 32 | 64% |
| Scientists | 15 | 30% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 441 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 3% |
| France | 4 | <1% |
| United Kingdom | 3 | <1% |
| Portugal | 2 | <1% |
| Germany | 2 | <1% |
| Chile | 1 | <1% |
| Italy | 1 | <1% |
| Austria | 1 | <1% |
| Spain | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 413 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 117 | 27% |
| Student > Ph. D. Student | 109 | 25% |
| Student > Bachelor | 35 | 8% |
| Student > Doctoral Student | 28 | 6% |
| Student > Master | 23 | 5% |
| Other | 75 | 17% |
| Unknown | 54 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 166 | 38% |
| Agricultural and Biological Sciences | 103 | 23% |
| Psychology | 39 | 9% |
| Medicine and Dentistry | 19 | 4% |
| Biochemistry, Genetics and Molecular Biology | 8 | 2% |
| Other | 29 | 7% |
| Unknown | 77 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 330. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2021.
All research outputs
#101,042
of 25,402,528 outputs
Outputs from Neuron
#116
of 9,547 outputs
Outputs of similar age
#2,067
of 351,784 outputs
Outputs of similar age from Neuron
#3
of 131 outputs
Altmetric has tracked 25,402,528 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,547 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,784 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.